The History of Breast Cancer Research and Treatment [Video]

The History of Breast Cancer Research and Treatment
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The history of breast cancer research and treatment is a fascinating journey marked by significant milestones and advancements over the centuries. Dating back to ancient times, Hippocrates first suggested that breast cancer was a systemic disease, setting the stage for evolving theories and treatments. In 1757, Henri Le Dran proposed surgical removal of the tumor as a treatment approach, which laid the foundation for surgical interventions in breast cancer. The 19th century saw pivotal developments with William Halsted introducing the radical mastectomy in 1882, a procedure that became the gold standard for decades.

Fast forward to the 20th century, the landscape of breast cancer treatment underwent a paradigm shift with the introduction of less invasive approaches. In 1937, Sir Geoffrey Keynes recommended radiation therapy in addition to surgery to spare the breast, marking a move towards more conservative treatments. The 1970s witnessed a turning point when Babette Rosmond challenged traditional radical mastectomies, sparking a shift towards alternative treatments and increased research efforts.

Key milestones in modern breast cancer research include the discovery of the human epidermal growth factor receptor 2 (HER2) gene in 1984, the creation of the pink ribbon for breast cancer awareness in 1992, and the identification of BRCA1 and BRCA2 genes in 1994–1995. These discoveries have not only enhanced our understanding of breast cancer but have also paved the way for targeted therapies and personalized treatment approaches. Today, early detection through methods like mammography and advancements in treatment options like trastuzumab (Herceptin) and anastrozole (Arimidex) have significantly improved outcomes for individuals with breast cancer.

The history of breast cancer research and treatment is a testament to the progress made in combating this disease, from ancient beliefs and practices to cutting-edge molecular subtyping and targeted therapies that define modern oncology.

00:00:00 The Ancient Understanding of Breast Cancer
00:00:54 The Dawn of Surgical Intervention
00:01:49 The Era of Radical Mastectomy
00:02:42 Towards Less Invasive Methods
00:03:35 HER2, BRCA1, and BRCA2
00:04:36 Early Detection and Advanced Treatments
00:05:38 The Continuum of Progress

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