Psychedelic Toad Venom Shows Promise for New Depression Treatment [Video]

A potential depression treatment might someday come from trip-inducing toad venom. In a new study Wednesday, researchers appear to have deciphered the structural workings of a psychedelic compound derived from the Colorado River toad (Incilius alvarius). The team also tested a modified version of the compound in mice, finding it had antidepressant and antianxiety effects, and potentially without the psychedelic reactions that could complicate its safe use in humans.

Lately, psychedelics like LSD and psilocybin (the active ingredient in magic mushrooms) have received plenty of scientific attention as possible treatments for mental illness. Several clinical trials are currently testing these drugs for conditions such as depression, anxiety, and post-traumatic stress disorder. In June, outside experts affiliated with the Food and Drug Administration will evaluate Phase III data on using MDMA-assisted psychotherapy for PTSD, and it’s almost certain that a positive verdict will clear the way for FDA approval later this year.