Phase II trial of cemiplimab and ISA101b vaccine in HPV16+ cervical cancer [Video]

Domenica Lorusso, MD, PhD, Fondazione IRCCS National Cancer Institute of Milan, Milan, Italy, comments on the Phase II trial (NCT04646005) evaluating cemiplimab with an ISA101b vaccine in recurrent HPV16-positive cervical cancer post-chemotherapy. The combination demonstrates clinical benefit in terms of overall response rate (ORR), and patients with higher PD-L1 expression showed greater ORR. These findings support further investigation of this combination. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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