Formation of Lung Cancer | Lung Cancer Symptoms | [Video]

Lung cancers arise from a single transformed epithelial cell in the tracheobronchial airways. A carcinogen (cigarette smoke, radon gas, other occupational and environmental agents) binds to a cell’s DNA and damages it. This damage results in cellular changes, abnormal cell growth, and eventually a malignant cell.

As the damaged DNA is passed on to daughter cells, the DNA undergoes further changes and becomes unstable. With the accumulation of genetic changes, the pulmonary epithelium undergoes malignant transformation from normal epithelium to eventual invasive
carcinoma.

More than 85% of lung cancers are caused by the inhalation of carcinogenic chemicals, most commonly cigarette smoke .

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