April Webinar: Pancreatic Cancer and Master Regulator Analysis [Video]

Our April Webinar is presented by Dr. Basil Bakir, the recipient of the 2023 Fellowship in Cancer Informatics and Data Science Research from the Pancreatic Cancer Action Network (PANCAN). Dr. Bakir presents his ongoing research to discover the master regulator genes that may determine which treatments patients will best respond to. From the abstract:

Pancreatic cancer is a challenging disease with 5-year survival rates of ~10%. One contributing factor to these outcomes is that there are few biomarkers to guide chemotherapy decisions. We propose to discover predictive biomarkers of chemotherapy sensitivity by applying (a) first regulatory network and (b) then master regulator analysis to the annotated molecular-clinical dataset in the Pancreatic Cancer Action Network SPARK database. Regulatory network and master regulator analysis are complementary techniques that permit the generation of a reverse-engineered transcriptional network for a given tissue type and then the inference of critical protein signaling nodes – termed master regulators – from that network.

Learn more about the Pancreatic Cancer Action Network: https://pancan.org/